Empowering scientists to reach for the edge of the possible

Programme Funding

Precision Mitochondria: Concept papers

ARIA is launching a programme backed by at least £55 million to make the mitochondrial genome programmable in vivo. The immediate goal is to achieve persistent, reproducible expression of a novel gene from engineered mitochondrial DNA (mtDNA) in a vertebrate system. The programme will fund the creation of a versatile toolkit to empower researchers with new capabilities. This toolkit will enable the delivery of nucleic acids into the mitochondrial matrix, the expression of functional proteins from the introduced genetic code, and the maintenance of engineered genomes through cellular replication.

AI Scientist

We are inviting proposals for a series of short exploratory projects to be undertaken by existing AI systems capable of performing the full end-to-end workflow of scientific knowledge creation. We are specifically looking for AI systems that can handle ideation and hypothesis creation, the design of experiments to test these hypotheses, the ability to run experiments in ideally fully automated labs, and the interpretation of results to draw conclusions. The AI system should be able to place its work in the context of related literature and produce a comprehensive written report detailing the related work, the idea explored, experiments, results, and conclusions. Please note that this is NOT a call to fund the development of a new AI Scientist system; you are expected to have an already functioning platform which can be used to attempt to solve a research problem.