Precision Mitochondria

Document type: Programme thesis

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Author: Nathan Wolfe

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Date published: 30 April 2025

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Version: 1

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DOI: https://doi.org/10.67475/pmecc6-n78c

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Abstract

This programme aims to unlock a transformative capability: to reliably and effectively engineer vertebrate mitochondrial DNA (mtDNA) in vivo. Success would establish a foundational, versatile toolkit to systematically study, manipulate, and ultimately reprogramme mitochondrial DNA, opening the door to a powerful new class of therapeutics across ageing and chronic disease. In the long term, this could include rewiring mitochondria for new metabolic capabilities or even functions as biosensors or in situ therapeutic factories.