Sustained Viral Resilience
Backed by £57m, this programme sits within the Sculpting Innate Immunity opportunity space and seeks to create a new class of medicines that provide durable, broad-spectrum protection against respiratory viruses by engineering the innate immune system.
Meet the R&D Creators
We’re funding 11 teams to create sustained innate immunoprophylactics (SIIPs): a new class of medicines that provide durable, broad-spectrum protection against respiratory viruses by engineering the innate immune system.
This portfolio cuts across three Technical Areas: Explorers, Accelerators, and Translators. Together, they’ll design, build, and test SIIP candidates; develop the tools and platforms to accelerate the process of bringing these candidates to proof-of-concept; and facilitate SIIPs’ future clinical translation and commercialisation.
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TA1 | Explorers
We’re funding seven teams to design, build, and test SIIP candidates, providing proof-of-concept evidence that this new class of medicines is possible.
Towards a universal vaccine: inducing durable immunity that transcends pathogen boundaries
Bali Pulendran, Stanford University
epiPRIME: epigenetically programmed resilience through innate memory engineering
Chiara Herzog, University of Cambridge
ASPIRE: anti-sense mediated state programming for respiratory epithelial defence
Thushan de Silva, University of Sheffield
AEGIS: anti-viral engineered opsonin based innate immune shielding
Aaron Scott, University of Birmingham
TRIUMPH-NK
Salim Khakoo, University of Southampton
MAGIC: MAIT cell activation to generate innate control
Paul Klenerman, University of Oxford
Development of synthetic MDA5 agonists to provide sustained innate immunity
Jan Rehwinkel, University of Oxford
“Our goal is to provide broad, long-lasting protection against multiple respiratory pathogens. ARIA's vision and support create a unique opportunity to translate a fundamentally new concept in immunology from the laboratory into human studies, with the potential to transform global health and pandemic preparedness.”
Bali Pulendran
Stanford University
Opportunity spaces
We help exceptional scientists and engineers turn their ideas into reality.
Funding at ARIA
Learn more about how we fund and explore our funding opportunities.